The 35-year-old, a three-time Champions League and
eight-time La Liga winner with boyhood club Barcelona, revealed the news in a
video message posted on his social media.
"Football has given me everything," he said.
"Barcelona has given me everything. You, culers (Barcelona fans), have
given me everything.
"And now that [this] kid's dreams have come true, I
want to tell you that I've decided that now is the time to bring this journey
to its end."
Pique, who won 102 caps for Spain and helped them to victory
in the 2010 World Cup, has become a peripheral figure for Barcelona this
season, making only five starts.
However, the former Manchester United defender wants his
boyhood club to be his last, saying: "I've always said that there would
not be any other team after Barca and that's how it will be."
Pique finished his statement by hinting at a future return
to the club in a non-playing capacity.
"This Saturday's game will be my last at Camp
Nou," he said. "I will become a regular fan. I will support the team.
I will pass my love for Barcelona to my children.
"And you know me - sooner or later, I'll be back."
Following his decision to bring his playing career to an
end, Barcelona described Pique - who was born in the city and whose grandfather
was on the club's board - as a "member since birth".
He came through the famed La Masia academy but made his
debut for United in 2004 after moving to Old Trafford as a 17-year-old earlier
that year.
Pique won the League Cup, Premier League and Champions
League under Sir Alex Ferguson but made only 23 appearances during his
four-year spell in England and eventually returned to Barcelona under the
newly-appointed Pep Guardiola.
Under the former Barca midfielder, Pique became a key player
for the club he supports, helping them to three La Liga titles and two Copa del
Reys, plus two Champions League titles, two European Super Cup wins and victory
in two Club World Cups.
Pique remained a vital member of the Barcelona side
following Guardiola's exit, winning another 13 major trophies in the 11 years
since the manager left the club.
The 35-year-old was also central to Spain's success and
played every minute of the 2010 World Cup final win over the Netherlands and
the 2012 Euros victory against Italy, before ending his international career
after the 2018 World Cup.